Kobayakawa Sena is a freshman in highschool. Despite his previous decisions to change his life, he finds himself in the exactly same place he was in during elementary school and junior high: a push over and an errand boy. However, this changes when Hiruma, the most feared person in his school and president of the American Football Club, notices Sena and forces him to join the Football Team. Now Sena will become Eyeshield 21, a mysterious running back with lighting fast speed.